One single study, multiple effects

Until now, there is only one published study on indolepropionamide and its effect on aging [1]. The team used rotifers, a micro-organism model for which they observed an increase in lifespan unequaled by other molecules. This longevity was accompanied by better cell repair and increased resistance to injury.

The study concludes that this effect is due to a drastic improvement in mitochondrial function accompanied by a significant reduction in the formation of free radicals. The amazing antioxidant properties of indolepropionamide are linked to its structure, very close to that of the hormone melatonin, and to its ability to interact with the oxidative phosphorylation chain of mitochondria. Indeed, it is likely that indolepropionamide is capable of stabilizing mitochondrial energy metabolism by binding to the complex I of the respiratory chain, thus causing a decrease in oxidant production. One of its close cousins, 3-indolepropionic acid,  shares the structural homology to melantonin and has been attributed the same type of properties. This molecule is currently undergoing clinical trials to fight Alzheimer’s disease.

Although new studies are needed, particularly in mammals, indolepropionamide is an extremely promising molecule and its derivatives already seem to offer good prospects, particularly in the fight against neurodegenerative diseases. Moreover, indolepropionamide is an amphiphilic molecule, thus passing as well the cellular membranes as the aqueous structures, and its bioavailability is excellent.

• Number publications : 1
• Availability : not available for sale
• Route : intravenous
• Dosage : to be defined